DocumentCode
2767985
Title
A software package for next-gen bisulfite sequencing data analysis
Author
Choi, Jeong-Hyeon ; Ryu, Dong-Sung ; Sureshchandra, Suhas ; Shi, Huidong ; Cho, Hwan-Gue
Author_Institution
Cancer Center, Georgia Health Sci. Univ., Augusta, GA, USA
fYear
2011
fDate
12-15 Nov. 2011
Firstpage
1061
Lastpage
1062
Abstract
Bisulfite sequencing (BS-seq) is one of the most important sequencing protocols for genome-wide DNA methylation studies. However, it causes significant challenges in computation because it converts unmethylated cytosines to thymines. This paper presents a software package to address those challenges and to provide various kinds of analysis modules, from mapping to comparing multiple samples.
Keywords
DNA; data analysis; genomics; medical computing; software packages; BS-seq; genome-wide DNA methylation studies; next-gen bisulfite sequencing data analysis; sequencing protocols; software package; thymines; unmethylated cytosines; Bioinformatics; Computational efficiency; DNA; Diseases; Genomics; Pipelines; Software packages; DNA methylation; bisulfite sequencing; next-gen sequencing;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedicine Workshops (BIBMW), 2011 IEEE International Conference on
Conference_Location
Atlanta, GA
Print_ISBN
978-1-4577-1612-6
Type
conf
DOI
10.1109/BIBMW.2011.6112561
Filename
6112561
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