Novel type of microcantielver biosesor resonating at the interface between liquid and air

We developed a new type of a microcantilever biosensor resonating at the interface between air and liquid. The cantilever sensor has advantages in high signal-to-noise ratio (SNR) and high quality factor (Q-factor) for detecting bio-reactions because liquid damping acts on only one-side, and because there is no obstacle between detection, excitation lasers and the cantilever. (Fig. 1 (c)) Using the cantilever integrated with a microchannel and phase locked loop detection, we measured adsorption reaction kinetics of carboxylated microspheres in real time for three different concentrations.