• DocumentCode
    2769974
  • Title

    Synthesis of 18F-labeled probes on EWOD platform for Positron Emission Tomography (PET) preclinical imaging

  • Author

    Chen, S. ; Keng, P.Y. ; van Dam, R.M. ; Kim, C.-J.

  • Author_Institution
    Bioeng. Dept., Univ. of California, Los Angeles, Los Angeles, CA, USA
  • fYear
    2011
  • fDate
    23-27 Jan. 2011
  • Firstpage
    980
  • Lastpage
    983
  • Abstract
    We demonstrate the synthesis of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) on an electrowetting-on-dielectric (EWOD) platform using multifunctional electrodes (for heating, temperature sensing, and EWOD driving). A revised chemistry to incorporate advantages of microfluidic volumes is used to produce multiple doses of PET tracer for preclinical imaging. The success is confirmed by imaging mice with radiotracers produced on chip. This is an important step toward the development of an affordable, universal synthesizer for imaging tracers used in Positron Emission Tomography (PET).
  • Keywords
    bioMEMS; biomedical electrodes; lab-on-a-chip; microfluidics; positron emission tomography; radioactive tracers; radioisotope imaging; 2-[18F]fluoro-2-deoxy-D-glucose; 18F-labeled probe synthesis; EWOD driving; EWOD platform; PET preclinical imaging; electrowetting-on-dielectric platform; heating; imaging tracers; microfluidic volumes; multifunctional electrodes; positron emission tomography; radiotracers; temperature sensing; Electrodes; Mice; Positron emission tomography; Solvents; Water heating;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Micro Electro Mechanical Systems (MEMS), 2011 IEEE 24th International Conference on
  • Conference_Location
    Cancun
  • ISSN
    1084-6999
  • Print_ISBN
    978-1-4244-9632-7
  • Type

    conf

  • DOI
    10.1109/MEMSYS.2011.5734591
  • Filename
    5734591
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=2769974