Integration of high-efficiency capture and magneto-hydrodynamic retrieval of particles on a centrifugal microfluidic platform

This work presents for the first time a centrifugal platform which fully integrates efficient centrifugal trapping, retention and release of particles from an array of geometrical V-cup structures through novel magneto-hydrodynamic pumping principle. This mechanical actuator represents a band pass which is inactive at the high rotational frequencies required in a first trapping and assay phase while inducing hydrodynamic pumping for recovering the trapped particles from the V-cups at low frequencies. The merely frequency-controlled operation will allow an instrumentally very simple implementation of cell-based screening and subsequent off-chip analysis.