Composite kernel based SVM for hierarchical multi-label gene function classification

This paper proposes a hierarchical multi-label classification method based on SVM with composite kernel for solving gene function prediction. The hierarchical multi-label classification problem is resolved into a set of binary classification tasks. A composite kernel based SVM (ck-SVM) is introduced to deal with the binary classification tasks. In estimation procedure of ck-SVM, a supervised clustering with over-sampling strategy is introduced for solving imbalance dataset learning problem and improve classification performance. Experimental results on benchmark datasets demonstrate that the proposed method improves the classification performance efficiently.