Title :
Measuring and Mapping Optical Properties and Chromophore Changes During Brain Injury in the Near-Infrared Spectral Range Using Spatial Modulation of Light: Initial Results
Author :
Abookasis, David ; Mathews, Marlon S. ; Lay, Christopher ; Frostig, Ron D. ; Linskey, Mark E. ; Tromberg, Bruce J.
Author_Institution :
Beckman Laser Inst. & Med. Clinic, California Univ., Irvine, CA
Abstract :
In this paper we describe the use of spatially modulated light projection for quantifying changes in chromophores during acute ischemic injury in the rat barrel cortex. The approach we use is based on spatial modulation of white light projected onto the brain by commercial projector. The reflected light is acquired on a CCD camera, which is then processed in the computer to obtain the concentration and distribution of chromophores through steady-state diffusion model. Experimental results from permanent stroke model underline the performance of the suggested techniques.
Keywords :
bio-optics; biological effects of optical radiation; biomedical optical imaging; medical image processing; acute ischemic injury; brain injury; chromophore changes; chromophore distribution; near-infrared spectral range; rat barrel cortex; spatial modulation; spatially modulated light projection; steady-state diffusion model; white light; Arteries; Biomedical imaging; Biomedical optical imaging; Brain injuries; Ischemic pain; Medical diagnostic imaging; Optical films; Optical imaging; Optical modulation; Optical saturation;
Conference_Titel :
Neural Engineering, 2007. CNE '07. 3rd International IEEE/EMBS Conference on
Conference_Location :
Kohala Coast, HI
Print_ISBN :
1-4244-0792-3
Electronic_ISBN :
1-4244-0792-3
DOI :
10.1109/CNE.2007.369654
