Measuring and Mapping Optical Properties and Chromophore Changes During Brain Injury in the Near-Infrared Spectral Range Using Spatial Modulation of Light: Initial Results

In this paper we describe the use of spatially modulated light projection for quantifying changes in chromophores during acute ischemic injury in the rat barrel cortex. The approach we use is based on spatial modulation of white light projected onto the brain by commercial projector. The reflected light is acquired on a CCD camera, which is then processed in the computer to obtain the concentration and distribution of chromophores through steady-state diffusion model. Experimental results from permanent stroke model underline the performance of the suggested techniques.