The Electrocorticogram as a Feedback Control Signal for Deep Brain Stimulation of the Subthalamic Nucleus in the hemi-Parkinsonian Rat

Electrocorticogram (ECoG) recordings of the 6-OHDA lesioned rat have shown an increase in the power of beta (15-30 Hz) oscillatory frequency on the lesioned side of the brain which reduces with dopamine agonist administration. Here, we were able to demonstrate that implantation and stimulation of an electrode at certain physiologic parameters in the subthalamic nucleus was able to modify the power of the beta oscillations. By measuring ECoG recordings, a deep brain stimulation (DBS) device may be able to vary its parameters to achieve a reduction in p power similar to that seen with medication.