Alpha-amylase activity of tannin isolated from Terminalia chebula

Author

Mukherjee, Sayan ; Mitra, Abhijit ; Dey, Satyahari ; Thakur, Goutam

Author_Institution

Sch. of Med. Sci. & Technol., Indian Inst. of Technol. Kharagpur, Kharagpur, India

fYear

2010

fDate

16-18 Dec. 2010

Firstpage

443

Lastpage

445

Abstract

One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose. This is possible by inhibiting certain carbohydrate hydrolyzing enzymes like alpha-amylase. In the present study, the inhibitory effect of tannins isolated from the alcoholic extract of fruits of Terminalia chebula was evaluated for the first time with porcine pancreatic amylase and potato starch as substrate. The result indicated that highest inhibition (52%) was obtained at the concentration of 100μg/ml of tannins extracted from the fruits. The result was comparable to that of Acarbose which is a very effective antidiabetic agent.

Keywords

biological techniques; biomedical materials; enzymes; molecular biophysics; patient treatment; Terminalia chebula; acarbose; alpha-amylase activity; antidiabetic agent; carbohydrate hydrolyzing enzymes; fruit alcoholic extract; porcine pancreatic amylase; potato starch; tannin; therapeutic approach; type 2 diabetes mellitus treatment; Cancer; Diabetes; Educational institutions; Materials; Stress; Tumors; acarbose; alpha-amylase enzyme; postprandial; tannins; type 2 diabetes mellitus;

fLanguage

English

Publisher

ieee

Conference_Titel

Systems in Medicine and Biology (ICSMB), 2010 International Conference on

Conference_Location

Kharagpur

Print_ISBN

978-1-61284-039-0

Type

conf

DOI

10.1109/ICSMB.2010.5735421

Filename

5735421