Multiwalled carbon nanotubes-induced cytotoxic effects on human breast adenocarcinoma cell line

Author

Bellucci, Stefano ; Dinicola, S. ; Coluccia, P. ; Bizzarri, Mariano ; Catizone, A. ; Micciulla, F. ; Sacco, Ilaria ; Ricci, Giuseppe ; Cucina, A.

Author_Institution

INFN-Lab. Naz. di Frascati, Rome, Italy

Volume

1

fYear

2012

fDate

15-17 Oct. 2012

Firstpage

37

Lastpage

42

Abstract

Treatment of the human breast adenocarcinoma cell line, MCF-7, with 0.1 mg/ml of MWCNTs, MWCNTs-COOH, or MWCNTs-OH for 72 hours induced both a decrease in cell proliferation and a reduction of the percentage of cells in S-phase of cell cycle. Moreover, all types of MWCNTs induced an increase in apoptotic cells. Overall, these data indicated that the cytotoxic effects of all types of MWCNTs are mediated both from a decrease in the proliferation rate and from an increase of apoptotic cell death. The biological effects of all types of MWCNTs could be explained with their cellular internalization.

Keywords

cancer; carbon nanotubes; cellular biophysics; nanomedicine; patient treatment; toxicology; C; S-phase cell cycle; apoptotic cell death; apoptotic cells; biological effects; cell proliferation; cell reduction; cellular internalization; human breast adenocarcinoma cell line MCF-7 treatment; multiwalled carbon nanotubes-induced cytotoxic effects; time 72 hr; Breast; Carbon nanotubes; Educational institutions; Humans; USA Councils; carbon nanotubes; cytotoxic effects; human breast adenocarcinoma;

fLanguage

English

Publisher

ieee

Conference_Titel

Semiconductor Conference (CAS), 2012 International

Conference_Location

Sinaia

ISSN

1545-857X

Print_ISBN

978-1-4673-0737-6

Type

conf

DOI

10.1109/SMICND.2012.6400701

Filename

6400701