Evaluation of drug induced frequency dependent QT-prolongation using a flexible computer-based programmable stimulator

Author

Moertl, D. ; Gomez, M. ; Thaler, U. ; Todt, H. ; Porenta, G.

Author_Institution

Wien Univ., Austria

fYear

2000

fDate

2000

Firstpage

171

Lastpage

174

Abstract

The proarrhythmic potential of therapeutic drugs can be evaluated by in-vivo electrophysiological testing using stimulated bradycardias. Since conventional stimulators are limited in the number of bradycardic beats, they cannot be used to evaluate the dynamic change of QT-intervals from the onset of bradycardia until a steady state has been achieved. Therefore, we designed and implemented a computer-based programmable stimulator, that enables complex stimulation protocols. This application was then rested in an experimental guinea-pig model to evaluate the characteristics of droperidol-induced QT-interval prolongation

Keywords

drug delivery systems; electrocardiography; medical signal processing; pacemakers; ECG recording; QT-intervals; bradycardic beats; complex stimulation protocols; droperidol-induced QT-interval prolongation; drug induced frequency dependent QT-prolongation; dynamic change; flexible computer-based programmable stimulator; guinea-pig model; in-vivo electrophysiological testing; proarrhythmic potential; programmable pacemaker; steady state; stimulated bradycardias; therapeutic drugs; Application software; Biomedical monitoring; Delay estimation; Drugs; Frequency dependence; Heart rate; Heart rate measurement; Protocols; Steady-state; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 2000

Conference_Location

Cambridge, MA

ISSN

0276-6547

Print_ISBN

0-7803-6557-7

Type

conf

DOI

10.1109/CIC.2000.898483

Filename

898483