Title :
Three-dimensional active bidomain model for bipolar stimulation
Author :
Min, X. ; Eason, JC ; Mehra, R.
Author_Institution :
Medtronic Inc., Minneapolis, MN, USA
Abstract :
A 3D bidomain model with cardiac membrane dynamics was built to analyze excitation and propagation of electrical activity caused by a pacing stimulus. The objective of this study is to investigate the effect of orientation of a bipolar electrode and tissue fibers on pacing thresholds (PT) and propagation patterns, as well as the differences in results obtained by using two membrane models: Fitzhugh-Nagumo (FHN) and Luo-Rudy phase I (LRI). The results show that a 3D bidomain model with LRI kinetics allows simulation of realistic pacing stimuli and the simulations produce reasonable estimates of pacing threshold and conduction velocity. The pacing threshold with a vertical bipolar electrode is higher than with a horizontal bipole with either LRI of FHN
Keywords :
biocontrol; bioelectric potentials; biomedical electrodes; biomembrane transport; cardiology; pacemakers; physiological models; 3D bidomain model; Fitzhugh-Nagumo; Luo-Rudy phase I; bipolar electrode; bipolar stimulation; cardiac membrane dynamics; cardiac pacemakers; conduction velocity; electrical activity excitation; electrical activity propagation; horizontal bipole; membrane models; orientation effect; pacing stimulus; pacing thresholds; propagation patterns; realistic pacing stimuli; three-dimensional active bidomain model; tissue fibers; vertical bipolar electrode; Biomembranes; Blood; Conductivity; Electrodes; Equations; Extracellular; Geometry; Pacemakers; Solid modeling; Tensile stress;
Conference_Titel :
Computers in Cardiology 2000
Conference_Location :
Cambridge, MA
Print_ISBN :
0-7803-6557-7
DOI :
10.1109/CIC.2000.898522
