Hormone concentration inception: Development an artificial immune system with immunomodulator (AISI) intervention

Evolutionary computation is flourishingly used to solve combinatorial optimization problems nowadays. The proposed method is developed as an artificial immune system (AIS) which considers the influence of the immunomodulator (AISI), specifically, hormone concentration. The concept of hormone concentration is inducted into current AIS to adjust its decision making based on both large and small scale viewpoints. B-cells and antibodies are used to deal with small-scale responses because of the characteristics to neutralize high affinity antigens in a certain range. By contrast, the hormone concentration inception is associated with probability matrix has more advantages on large-scale responses. After testing on four databases, the proposed AISI system offered better overall performances to compare with the original AIS and the ant K-means (AK) system.