Intracellular Volume Registration

The paper proposes a novel 3D image registration approach to calculating intracellular volumes. The approach extends a standard image registration framework to the curved cell geometry. An intracellular volume is mapped onto another intracellular domain by using two pairs of point set surfaces approximating their nuclear and plasma membranes. The approach is implemented to an interactive volume registration system. We demonstrate that our approach can create models of cells with multiple organelles from data collected from living cells.