A fuzzy framework with prior information unifying registration, segmentation and bias field correction of brain MRI

This paper introduces a fuzzy framework for the simultaneous segmentation and registration in addition to bias field correction of MRI datasets. The framework utilizes prior information which may be available about the tissues´ mean intensities and tissues´ distribution through the datasets. Moreover it works on the given, original image intensities without any logarithmic transformation and thus produces more accurate results and faster performance. The algorithm is evaluated using simulated and real brain MRI data. The results show that the algorithm has indeed improved the segmentation accuracy.