Title :
Second-harmonic efficiency of single barium titanate nanoparticles used as biomarkers for cells imaging
Author :
Grange, R. ; Hsieh, C.-L. ; Pu, Y. ; Psaltis, D.
Author_Institution :
Opt. Lab., EPFL, Lausanne, Switzerland
Abstract :
We characterize the second-harmonic efficiency of a single 90-nm BaTiO3 nanoparticle. We demonstrate the biocompatibility by imaging cells with this new class of markers that we call Second Harmonic Radiative IMaging Probes (SHRIMPs). Compared to conventional fluorescent markers such as organic dyes or quantum dots, SHRIMPs possess several key advantages, including long-term observation without photobleaching, flexibility in excitation wavelength, coherent signals for three-dimensional imaging, narrow signal bandwidth for greater noise rejection, ultrafast response time, and excellent biocompatibility.
Keywords :
barium compounds; biomedical materials; biomedical optical imaging; nanobiotechnology; nanoparticles; optical harmonic generation; BaTiO3; Second Harmonic Radiative IMaging Probes; biocompatibility; biomarkers; cellular imaging; coherent signals; flexibility; long-term observation; narrow signal bandwidth; noise rejection; photobleaching; second-harmonic efficiency; single barium titanate nanoparticles; size 90 nm; ultrafast response time; Bandwidth; Barium; Biomarkers; Delay; Fluorescence; Nanoparticles; Photobleaching; Probes; Quantum dots; Titanium compounds;
Conference_Titel :
Lasers and Electro-Optics 2009 and the European Quantum Electronics Conference. CLEO Europe - EQEC 2009. European Conference on
Conference_Location :
Munich
Print_ISBN :
978-1-4244-4079-5
Electronic_ISBN :
978-1-4244-4080-1
DOI :
10.1109/CLEOE-EQEC.2009.5194757
