Tumor irrigation model for virotherapy cancer treatment

A novel virotherapy cancer model based on tumor capillarity irrigation is proposed and compared to previous developed models. The proposed model consists of blood irrigation layers distributed radially along the tumor and attached to a common blood circulation compartment. It also considers the immune system cell generation and consumption in the blood circulation compartment and its propagation inside the tumor boundary. The model equilibrium conditions result in a quadratic function for which the tumor radius reaches steady state under virotherapy. Such a condition permits determination of the minimum drug dose required to halt the cancer growth. This novel model has great potential for advanced controllers because therapy dose delivery and immune system measurements can actually be applied at the blood compartment.