Preparation and characterization of polymeric micelles for disinfectant coating of catheters

Author

Pheungkham, H. ; Ngambenjawong, C. ; Theerasilp, M. ; Nasongkla, N.

Author_Institution

Biomed. Eng. Dept., Mahidol Univ., Nakorn Pathom, Thailand

fYear

2012

fDate

20-23 Aug. 2012

Firstpage

1

Lastpage

4

Abstract

The disinfectant loaded micelle fabrication were investigated as a carrier for 2-benzyl-4-chlorophenol (OBPCP), a disinfectant agent. Micelles were assessed in terms of the drug entrapment efficiency by suitable fabrication process. Results showed that a film sonication method provided the highest drug loading density at 16.35 ± 0.52%. To utilize numerous advantages of these polymer micelles, micelles containing OBPCP were coated on the surface of catheters using Layer-by-layer (LbL) dip coating technique, highlighting the protocol as an improvement in the prolong release of the drug from a period of several hours to several weeks.

Keywords

catheters; colloids; dip coating; drugs; organic compounds; 2-benzyl-4-chlorophenol; LbL dip coating technique; OBPCP; catheter disinfectant coating; disinfectant agent; drug entrapment efficiency; drug loading density; fabrication process; film sonication method; layer-by-layer dip coating technique; polymeric micelle characterization; polymeric micelle preparation; Coatings; Drugs; Films; Loading; Polymers; Substrates; Surface treatment;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanotechnology (IEEE-NANO), 2012 12th IEEE Conference on

Conference_Location

Birmingham

ISSN

1944-9399

Print_ISBN

978-1-4673-2198-3

Type

conf

DOI

10.1109/NANO.2012.6403798

Filename

6403798