Title :
Preparation and characterization of polymeric micelles for disinfectant coating of catheters
Author :
Pheungkham, H. ; Ngambenjawong, C. ; Theerasilp, M. ; Nasongkla, N.
Author_Institution :
Biomed. Eng. Dept., Mahidol Univ., Nakorn Pathom, Thailand
Abstract :
The disinfectant loaded micelle fabrication were investigated as a carrier for 2-benzyl-4-chlorophenol (OBPCP), a disinfectant agent. Micelles were assessed in terms of the drug entrapment efficiency by suitable fabrication process. Results showed that a film sonication method provided the highest drug loading density at 16.35 ± 0.52%. To utilize numerous advantages of these polymer micelles, micelles containing OBPCP were coated on the surface of catheters using Layer-by-layer (LbL) dip coating technique, highlighting the protocol as an improvement in the prolong release of the drug from a period of several hours to several weeks.
Keywords :
catheters; colloids; dip coating; drugs; organic compounds; 2-benzyl-4-chlorophenol; LbL dip coating technique; OBPCP; catheter disinfectant coating; disinfectant agent; drug entrapment efficiency; drug loading density; fabrication process; film sonication method; layer-by-layer dip coating technique; polymeric micelle characterization; polymeric micelle preparation; Coatings; Drugs; Films; Loading; Polymers; Substrates; Surface treatment;
Conference_Titel :
Nanotechnology (IEEE-NANO), 2012 12th IEEE Conference on
Conference_Location :
Birmingham
Print_ISBN :
978-1-4673-2198-3
DOI :
10.1109/NANO.2012.6403798
