High signal to noise ratio in low field NMR on chip, simulations and experimental results

Author

Wensink, H. ; Hermes, D.C. ; van den Berg, A.

Author_Institution

Inst. for Nanotechnol., Twente Univ., Enschede, Netherlands

fYear

2004

fDate

2004

Firstpage

407

Lastpage

410

Abstract

A μfluidic chip with integrated microcoil was developed for nuclear magnetic resonance (NMR) spectroscopy on limited volume samples (nanoliters range). This chip will be used for the online monitoring of micro chemical reactions. Design rules for the microcoil to achieve the best signal to noise ratio (SNR) were obtained by finite element simulation. For pure water in a low field NMR magnet (60 MHz., i.e. 1.4 Tesla) a SNR of 550 was achieved which is to our knowledge higher than any other μfluidic chip with integrated detection coil. It is also shown that a spectral resolution of 0.025 ppm is obtained when a microchannel with an arbitrary cross section is placed parallel to the magnetic field. A high SNR at low magnetic field for small volume samples is essential for the development of portable NMR systems where mini permanent magnets of 1 Tesla are used.

Keywords

NMR spectroscopy; finite element analysis; microfluidics; nuclear magnetic resonance; organic compounds; permanent magnets; μfluidic chip; 1 tesla; NMR on chip; finite element simulation.; integrated microcoil; micro chemical reactions; nuclear magnetic resonance spectroscopy; online monitoring; permanent magnets; signal to noise ratio; Chemicals; Coils; Finite element methods; Magnetic fields; Magnetic resonance; Monitoring; Nuclear magnetic resonance; Signal design; Signal to noise ratio; Spectroscopy;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems, 2004. 17th IEEE International Conference on. (MEMS)

Print_ISBN

0-7803-8265-X

Type

conf

DOI

10.1109/MEMS.2004.1290608

Filename

1290608