Title :
Surface enhanced Raman spectra in biochemical molecules and cell detection
Author :
Wang, Tsuei-Lian ; Peng, Fang-Ying ; Lu, Hui-Hsin ; Hung, Yung-Ta ; Fang, Tung-Jing ; Chiang, Huihua Kenny
Author_Institution :
Inst. of Biomed. Eng., Nat. Yang-Ming Univ., Taipei, Taiwan
Abstract :
This work presents the quantitative detection of creatinine molecules and SERS signal from a single cell. Through the utilization of gold nanoparticles, we can measure the lower concentration of specimens. In biochemical molecules analysis, quantification of creatinine in human urine sample is demonstrated. The correlation coefficient can be reached as high as 0.99 for mixture sample, and 0.93 for human subject analysis.
Keywords :
biochemistry; biomedical measurement; cellular biophysics; gold; molecular biophysics; nanoparticles; spectrochemical analysis; surface enhanced Raman scattering; Au; SERS; biochemical molecule; cell detection; correlation coefficient; creatinine molecule; gold nanoparticle; human urine sample; quantitative detection; surface enhanced Raman spectra; Band pass filters; Biomedical optical imaging; Gold; Humans; Optical scattering; Optical surface waves; Raman scattering; Rough surfaces; Spectroscopy; Surface roughness;
Conference_Titel :
Biophotonics, 2004. APBP 2004. The Second Asian and Pacific Rim Symposium on
Print_ISBN :
0-7803-8676-0
DOI :
10.1109/APBP.2004.1412276
