Title :
The effect of wild-type p53 on the response of K562 to EMP
Author :
Xue-Jun, Xie ; Yao, Guo ; Gui-Ying, Zeng ; Guo-Zheng, Guo
Author_Institution :
Dept. of Radiat. Medicine, Fourth Mil. Med. Univ., Xi´´an
Abstract :
The wild-type p53 is investigated whether it has an effect on apoptosis and cell cycle distribution of K562 cells after EMP irradiation. The K562 cells transfected with wild-type p53 were irradiated by EMP and then cultured for 18h. Apoptosis and cell cycle were detected by FCM. Apoptosis and G1 arrest were induced by p53 transfection. No effect of EMP was detected on cell cycle and apoptosis of K562 cells with different p53 statuses. Exposure to EMP has no effects on K562 cells before and after p53 gene transfection
Keywords :
biological effects of fields; cellular effects of radiation; electromagnetic pulse; EMP; K562 response; apoptosis; cell cycle distribution; p53 gene transfection; wild-type p53; Biomembranes; Cells (biology); DNA; Dairy products; EMP radiation effects; Electromagnetic fields; Electromagnetic induction; Humans; Pediatrics; Proteins; apoptosis; cell cycle; electromagnetic pulses; p53 gene;
Conference_Titel :
Environmental Electromagnetics, The 2006 4th Asia-Pacific Conference on
Conference_Location :
Dalian
Print_ISBN :
1-4244-0183-6
DOI :
10.1109/CEEM.2006.257970
