Spiral wave meandering in models of ventricular tissue as an antiarrhythmic target

We characterise the effects of ionic conductance and concentration changes on the meandering patterns and dynamics of re-entrant excitation in models of mammalian ventricular tissue. An increase in the spatial extent of spiral wave meander might lead to an increased likelihood of self-termination of the re-entrant excitation, since the probability of the spiral core meeting and annihilating at the in-excitable tissue boundaries is increased. Thus, the spiral-wave meandering behaviour and dynamics provides a potential target for antiarrhythmic drugs.