Title :
An Integrated Patch-Clamp Amplifier for High-Density Whole-Cell Recordings
Author :
Weerakoon, Pujitha ; Klemic, Kate ; Sigworth, Fred J. ; Culurciello, Eugenio
Author_Institution :
Electr. Eng. Dept., Yale Univ., New Haven, CT
Abstract :
We fabricated an integrated patch-clamp amplifier capable of recording nano-amperes of current in whole-cell patch recording. Patch-clamp amplifiers presently consist of a head-stage and a large controller box that contains many hundreds of components. Our design compresses the function of the head-stage and the controller box into one chip that can be mounted near the patch-clamp electrode and can be controlled through a high-speed serial bus paving the way for higher densities in parallel patch-clamp systems. We report on the electrical measurements from the fabricated device.
Keywords :
amplifiers; bioelectric phenomena; electrical measurements; high-speed serial bus; integrated patch-clamp amplifier; patch-clamp electrode; whole-cell patch recording; Biomembranes; Control systems; Current measurement; Drugs; Electric variables measurement; Electrodes; Feedback; Integrated circuit measurements; Low-noise amplifiers; Radiofrequency amplifiers;
Conference_Titel :
Circuits and Systems, 2007. ISCAS 2007. IEEE International Symposium on
Conference_Location :
New Orleans, LA
Print_ISBN :
1-4244-0920-9
Electronic_ISBN :
1-4244-0921-7
DOI :
10.1109/ISCAS.2007.378324
