Wireless wrist-wearable wake/sleep identification device for closed-loop deep brain stimulation

Deep brain stimulation is an important therapy for Parkinson´s disease patients. However, the current deep brain stimulator is open loop and cannot automatically adapt the stimulation according to the patient´s condition. In this reported study a real-time wake/sleep identification device has been developed to wirelessly control the stimulation according to the patient´s wake/sleep states. The wake/sleep identification was based on the wrist movement, and the identified result was transmitted wirelessly to the implantable pulse generator. This device showed a reliable radio frequency communication within 2 m and a low level of current consumption. This device also showed a good performance of real-time wake/sleep identification on Parkinson´s disease patients. This study provides a promising application in the closed-loop deep brain stimulation, as well as other applications in medical services, such as night care, and fall alarm.