DocumentCode
2903508
Title
Early stage dynamics modeling of the feed-forward loops with miRNA
Author
Duk, M.A. ; Samsonov, A.M. ; Samsonova, M.G.
Author_Institution
Ioffe Inst., St. Petersburg, Russia
fYear
2013
fDate
27-31 May 2013
Firstpage
42
Lastpage
46
Abstract
MicroRNAs or miRNAs are small non-coding RNA molecules, containing about 20 nucleotides only, but they are very important in regulatory gene networks. miRNAs repress target protein production at post-transcriptional level, but real mechanism of regulation is not absolutely clear. Moreover, the models may show the same steady state concentrations of components for different biological cases, and only study the early stage dynamics can help in choosing the most appropriate model.
Keywords
RNA; feedforward; genetics; molecular biophysics; molecular configurations; proteins; biological cases; early stage dynamics modeling; feed-forward loops; microRNAs; nucleotides; post-transcriptional level; regulatory gene networks; small noncoding RNA molecules; steady state concentrations; target protein production; Degradation; Diffraction; Proteins;
fLanguage
English
Publisher
ieee
Conference_Titel
Days on Diffraction (DD), 2013
Conference_Location
St. Petersburg
Print_ISBN
978-1-4799-1037-3
Type
conf
DOI
10.1109/DD.2013.6712801
Filename
6712801
Link To Document