• DocumentCode
    2903598
  • Title

    Mathematical model based on the Jeffreys type equation for description of gene expression

  • Author

    Gula, I.A. ; Samsonov, A.M.

  • Author_Institution
    Ioffe Phys. Tech. Inst., St. Petersburg, Russia
  • fYear
    2013
  • fDate
    27-31 May 2013
  • Firstpage
    72
  • Lastpage
    77
  • Abstract
    The classical diffusion model widely used for description of transport processes results, in general, in an infinite velocity of particles propagation. It is hardly applicable to the description of protein transport in biological systems, containing heavy molecules. In the 1950s the Jeffreys type equation was applied to govern the motion of rheological substances. Later, using this equation, the transport problem statement was modified to consider the gene expression in fruit fly embryo, and the model equation for protein concentration was proposed. The numerical solution of the coupled Jeffreys type equations with nonlinear terms is found for description of gap gene expression in early Drosophila embryo development and compared with the experimental data.
  • Keywords
    biochemistry; cellular transport; genetics; molecular biophysics; numerical analysis; physiological models; proteins; Drosophila embryo development; Jeffreys-type equation; biological systems; classical diffusion model; fruit fly embryo; gene expression; mathematical model; numerical solution; particle propagation; protein concentration; protein transport; rheological substances; transport processes; Biological system modeling; Data models; Embryo; Equations; Mathematical model; Numerical models; Proteins;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Days on Diffraction (DD), 2013
  • Conference_Location
    St. Petersburg
  • Print_ISBN
    978-1-4799-1037-3
  • Type

    conf

  • DOI
    10.1109/DD.2013.6712806
  • Filename
    6712806