Enhancement of adriamycin cytotoxicity by therapeutic ultrasound in vivo

Author

Saad, Alie H. ; Hahn, George M.

Author_Institution

Dept. of Radiat. Oncol., Stanford Univ., CA, USA

fYear

1989

fDate

3-6 Oct 1989

Firstpage

961

Abstract

A report is presented on the enhancing effect of ultrasound upon adriamycin (Adr) antitumor action in vivo. RIF-1 tumors were insonated ( F=1.733 MHz) 10 min after the intravenous injection of Adr (10 and 20 μg/g). This resulted in an increase in the tumor doubling time and a decrease in the TCD₅₀ when compared to ultrasound treatment alone or to the combination of water-bath heating of the tumor and Adr. The enhancement was dependent upon the dose of Adr injected, the intensity of sonication, and the temperature of the tumor. The results suggest that nonthermal mechanisms of ultrasound action are responsible for potentiation of Adr toxicity. The lack of ultrasound enhancement of daunomycin cytotoxicity in vitro is discussed

Keywords

biological effects of acoustic radiation; biomedical ultrasonics; cellular effects of radiation; radiation therapy; 1.733 MHz; 10 min; RIF-1 tumors; adriamycin cytotoxicity; daunomycin cytotoxicity; intravenous injection; nonthermal mechanisms; sonication intensity; therapeutic ultrasound; tumor doubling time; tumor temperature; water-bath heating; Drugs; In vitro; In vivo; Oncology; Piezoelectric transducers; Skin neoplasms; Temperature dependence; Ultrasonic imaging; Ultrasonic transducers; Water heating;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 1989. Proceedings., IEEE 1989

Conference_Location

Montreal, Que.

Type

conf

DOI

10.1109/ULTSYM.1989.67131

Filename

67131