Conformational dynamics and acoustic absorption in protein solution

Author

Slutsky, L.J. ; Allin, C.D. ; Madsen, L. ; Brady, J.

Author_Institution

Dept. of Chem., Washington Univ., Seattle, WA, USA

fYear

1989

fDate

3-6 Oct 1989

Firstpage

965

Abstract

Measurements of the frequency dependence of ultrasonic absorption in dilute aqueous solutions of bacitracin A from 140 kHz to 310 MHz are reported. An estimate of the contribution of conformational fluctuations to the high-frequency ultrasonic absorption, based on the frequency spectrum of volume fluctuations deduced from a molecular-dynamics simulation of bacitracin, is reported and discussed. It is concluded that models in which the solvent is ignored or represented as a viscous continuum do not adequately account for the relaxation spectrum

Keywords

bioacoustics; macromolecular configurations; macromolecular dynamics; molecular biophysics; proteins; ultrasonic absorption; 140 kHz to 310 MHz; HF US absorption; acoustic absorption; bacitracin; conformational fluctuations; dilute aqueous solutions; frequency dependence; molecular-dynamics simulation; protein conformational dynamics; protein solution; relaxation spectrum; viscous continuum; volume fluctuations; Absorption; Acoustic measurements; Chemistry; Fluctuations; Frequency estimation; Frequency measurement; Proteins; Pulse measurements; Solvents; Ultrasonic variables measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 1989. Proceedings., IEEE 1989

Conference_Location

Montreal, Que.

Type

conf

DOI

10.1109/ULTSYM.1989.67132

Filename

67132