Title :
Conformational dynamics and acoustic absorption in protein solution
Author :
Slutsky, L.J. ; Allin, C.D. ; Madsen, L. ; Brady, J.
Author_Institution :
Dept. of Chem., Washington Univ., Seattle, WA, USA
Abstract :
Measurements of the frequency dependence of ultrasonic absorption in dilute aqueous solutions of bacitracin A from 140 kHz to 310 MHz are reported. An estimate of the contribution of conformational fluctuations to the high-frequency ultrasonic absorption, based on the frequency spectrum of volume fluctuations deduced from a molecular-dynamics simulation of bacitracin, is reported and discussed. It is concluded that models in which the solvent is ignored or represented as a viscous continuum do not adequately account for the relaxation spectrum
Keywords :
bioacoustics; macromolecular configurations; macromolecular dynamics; molecular biophysics; proteins; ultrasonic absorption; 140 kHz to 310 MHz; HF US absorption; acoustic absorption; bacitracin; conformational fluctuations; dilute aqueous solutions; frequency dependence; molecular-dynamics simulation; protein conformational dynamics; protein solution; relaxation spectrum; viscous continuum; volume fluctuations; Absorption; Acoustic measurements; Chemistry; Fluctuations; Frequency estimation; Frequency measurement; Proteins; Pulse measurements; Solvents; Ultrasonic variables measurement;
Conference_Titel :
Ultrasonics Symposium, 1989. Proceedings., IEEE 1989
Conference_Location :
Montreal, Que.
DOI :
10.1109/ULTSYM.1989.67132
