Regression-based label fusion for multi-atlas segmentation

Automatic segmentation using multi-atlas label fusion has been widely applied in medical image analysis. To simplify the label fusion problem, most methods implicitly make a strong assumption that the segmentation errors produced by different atlases are uncorrelated. We show that violating this assumption significantly reduces the efficiency of multi-atlas segmentation. To address this problem, we propose a regression-based approach for label fusion. Our experiments on segmenting the hippocampus in magnetic resonance images (MRI) show significant improvement over previous label fusion techniques.