Dynamic prediction of cellular responding ion radiation (IR) based on an improved modeling of P53 stress response networks

Under acute genome stresses, P53, a vital anticancer gene, trigger the cell cycle arrest and cell apoptosis by regulating the downstream genes and the complicated signal pathways. To simulate the cellular responding DNA damage under different IR dose domains, an improved model of P53 stress response networks is proposed at single cell level. The model can be used to investigate the dynamic and kinetic processes of P53 stress response networks under different IR dose. Also, it can present the plausible outcomes of cellular response in fighting against DNA damage.