Identifying synergistic transcriptional factors involved in the yeast cell cycle using Microarray and ChIP-chip data

Knowing the synergistic activities of multiple transcription factors (TFs) is important for revealing the underlying mechanisms of transcription regulation in eukaryotic organisms. Based on the microarray data and ChIP-chip data, we identified the synergistic TF pairs and triplets involved in the yeast cell cycle. The results indicate that: (1) about one third of the predicted synergistic TF pairs, including five novel pairs undiscovered by previous computational methods, are supported by literature evidences; (2) the cell cycle transcription regulation synergistic TF triplet, FKH2-MCM1-NDD1, has been successfully predicted