Nano/micro lipid monodispersed droplets formation based on flow instability

In this paper, we report a novel method to generate sub-micron size droplet. By suitably designing the micro-channel device and controlling the fluids, we can induce the occurs of Kelvin-Helmholtz instability to make a lot of droplet forming with a sub-micron diameter. The size is much smaller than droplet generated by most physical or mechanical method. Further, we observe the process of sub-micron droplet formation with high speed camera and high magnification optical microscope.