Title :
A continuum model of the retinal network and its response to electrical stimulation
Author :
Yin, Shijie ; Lovell, Nigel H. ; Suaning, Gregg J. ; Dokos, Socrates
Author_Institution :
Grad. Sch. of Biomed. Eng., Univ. of New South Wales, Sydney, NSW, Australia
fDate :
Aug. 31 2010-Sept. 4 2010
Abstract :
A continuum network model of the retina is presented, consisting of an active implementation of the retinal ganglion cell tissue layer and passive implementation of deeper cell layers. The retinal ganglion cell layer receives excitatory presynaptic inputs from the bipolar layer and inhibitory presynaptic inputs from the amacrine layer. Simulations were performed to investigate the behavior of retinal tissue activation with epiretinal and suprachoroidal electrode stimulation. The results indicated the presence of both early and late onset action potentials consistent with experimental findings.
Keywords :
bioelectric potentials; biomedical electronics; cellular biophysics; eye; neuromuscular stimulation; physiological models; action potentials; amacrine layer; bipolar layer; continuum network model; electrical stimulation; epiretinal electrode stimulation; excitatory presynaptic inputs; inhibitory presynaptic inputs; retinal ganglion cell tissue layer; suprachoroidal electrode stimulation; Biomembranes; Electric potential; Electrical stimulation; Electrodes; Extracellular; Rabbits; Retina; Action Potentials; Algorithms; Animals; Biophysics; Computer Simulation; Electric Stimulation; Electrodes; Equipment Design; Humans; Models, Statistical; Rabbits; Retina; Time Factors;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE
Conference_Location :
Buenos Aires
Print_ISBN :
978-1-4244-4123-5
DOI :
10.1109/IEMBS.2010.5626300
