MML toolkit and work flow overview: Creating temporo-spatial heart models from CellML

Author

Chang, David C. ; Dokos, Socrates ; Lovell, Nigel H.

Author_Institution

Grad. Sch. of Biomed. Eng., Univ. of New South Wales, Sydney, NSW, Australia

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

1481

Lastpage

1484

Abstract

The Modeling Markup Language (MML) framework is a conceptual paradigm to quickly develop and solve biological models utilizing the CellML specification. In this study, we present the open source toolkit developed for this project and a possible workflow to create different scales of cardiac tissue models from a range of CellML models. Models from the CellML repository and other sources were tested for interoperability against the MML framework. Furthermore, to demonstrate the ability of the MML framework to deploy different scales of geometry, a model of atrial electrical activation is also presented.

Keywords

XML; bioelectric phenomena; biological tissues; cardiology; formal specification; medical computing; physiological models; public domain software; spatiotemporal phenomena; CellML models; CellML specification; MML toolkit; XML representation language; atrial electrical activation model; cardiac tissue models; modeling markup language toolkit; open source toolkit; temporo-spatial heart models; Biological system modeling; Computational modeling; Conductivity; Data models; Load modeling; Mathematical model; Storage area networks; Animals; Computer Graphics; Computer Simulation; Computer-Aided Design; Heart; Humans; Models, Anatomic; Software; Software Design; User-Computer Interface; Workflow;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5626847

Filename

5626847