Model-based optimal immunization for antibody production in birds

Author

Olarte, Andres ; Clavijo, Carlos ; Diaz, Hernando

Author_Institution

Dept. of Electr. Eng., Univ. Nac. de Colombia, Bogota, Colombia

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

1453

Lastpage

1456

Abstract

A dynamic model of the immune response in poultry was developed in order to enhance antibody production. Efficient production of antibodies is very valuable for researchers and physicians since they are used for other molecules detection. Large amounts of poultry-based antibodies are found in birds´ eggs. However, inoculation timetables are based on empirical data. A seven differential equation system represents cellular and molecular populations of the humoral immune response in poultry. Model parameters are presented and simulation results reflect the typical immune responses. Finally, a genetic algorithm was designed in order to optimize antibody production.

Keywords

biology computing; differential equations; genetic algorithms; veterinary medicine; zoology; antibody production; bird eggs; birds; cellular populations; differential equation system; dynamic model; genetic algorithm; humoral immune response; inoculation timetables; model-based optimal immunization; molecular populations; molecule detection; poultry-based antibodies; Biological system modeling; Birds; Equations; Immune system; Mathematical model; Production; Animals; Antibody Formation; Antigens; Birds; Computer Simulation; Immunity, Innate; Immunization; Models, Immunological;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5626860

Filename

5626860