Differential stimulation of ON and OFF retinal ganglion cells: A modeling study

Author

Kameneva, Tatiana ; Meffin, Hamish ; Burkitt, Anthony N.

Author_Institution

Dept. of Electr. Eng., Univ. of Melbourn, Melbourn, VIC, Australia

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

4246

Lastpage

4249

Abstract

A model of the electrophysiological properties of ON and OFF retinal ganglion cells (RGCs) was constrained and validated using experimental data from the literature. Our simulations support experimental findings that differences in the magnitude of the T-type Ca²⁺ current explain differences in the intrinsic electrophysiology of ON and OFF RGCs. The models are used to investigate the potential for differential stimulation of ON and OFF RGCs during neuroprosthetic stimulation with sinusoidal current. The model predicts that OFF cells fire preferential over ON cells in a frequency band around 10 Hz.

Keywords

bioelectric phenomena; cellular biophysics; eye; neurophysiology; RGC; T-type Ca²⁺ current; electrophysiological properties model; neuroprosthetic stimulation; off retinal ganglion cell; on retinal ganglion cell; retinal ganglion cell differential stimulation; sinusoidal current; Biomembranes; Data models; Electrical stimulation; Mathematical model; Neurons; Prosthetics; Retina; Animals; Calcium Channels, T-Type; Humans; Models, Biological; Patch-Clamp Techniques; Retinal Ganglion Cells;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5627176

Filename

5627176