Laboratory studies were done to determine the the persistence of hepatitis A virus (HAV) and poliovirus type 1 in experimentally contaminated Eastern oysters under depuration conditions. The effects of temperature (12, 17 and

C), salinity (8, 18 and 28 PPT ), and food supply in the form of the alga Isochrysis galbana, on virus depuration were studied. Under all test conditions, oysters reduced poliovirus by >98% in 2 to 3 days, but under most test conditions, HAV was generally reduced by no more than 90% in up to 5 days. However, HAV was reduced extensively (>95%) in oysters depurated at

C and 28 PPT salinity. The results of these studies indicate that HAV in contaminated oysters may not be reduced efficiently using some currently accepted depuration conditions.