Comparison of complex fractionated atrial electrograms at cellular scale using numerical and experimental models

Author

Navoret, Nicolas ; Xu, Binbin ; Jacquir, Sabir ; Binczak, Stéphane

Author_Institution

Lab. LE2I, Univ. de Bourgogne, Dijon, France

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

3249

Lastpage

3252

Abstract

This study investigates the existence of the pseudo complex fractionated atrial electrogram (CFAE) at cellular level. Our assumptions are based on the fact that CFAEs are linked to the generation of the spiral waves. These are created using a numerical model and an experimental model of in vitro culture of neonatal rats cardiac cells. Pseudo bipolar electrograms resulting from these two models are compared qualitatively and some patterns could be identified as CFAE signature.

Keywords

cellular biophysics; electrocardiography; physiological models; CFAE; complex fractionated atrial electrogram; neonatal rats cardiac cells; spiral waves; Electric potential; In vitro; Mathematical model; Numerical models; Rotors; Spirals; Substrates; Action Potentials; Animals; Atrial Fibrillation; Biological Clocks; Computer Simulation; Electrocardiography; Heart Atria; Heart Conduction System; Humans; Models, Cardiovascular; Myocytes, Cardiac;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5627235

Filename

5627235