Development of a microbicide-releasing diaphragm as an HIV prevention strategy

Author

Major, Ian ; Lowry, Deborah ; Malcolm, Karl ; Woolfson, David ; Cohen, Jessica ; LaBarre, Paul ; Kilbourne-Brook, Maggie ; Saxon, Gene ; Friend, David

Author_Institution

Sch. of Pharmacy, Queen´´s Univ. Belfast, Belfast, UK

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

1089

Lastpage

1092

Abstract

Contraceptive diaphragms offer a discreet method of pregnancy protection that women can use when needed with no side effects. Incorporating antiretroviral HIV microbicides into such devices may also provide protection against HIV infection. The paper gives a brief outline of the work being conducted by PATH, CONRAD and QUB on the development of a microbicide-releasing SILCS diaphragm. The design, engineering and manufacturing challenges that have been encountered will be discussed, as well as the potential impact such a device could have in the developing world.

Keywords

antibacterial activity; biomedical engineering; health care; medical supplies; microorganisms; pharmaceuticals; CONRAD; HIV prevention strategy; PATH; QUB; antiretroviral HIV microbicides; contraceptive diaphragms; microbicide releasing SILCS diaphragm; microbicide releasing diaphragm; pregnancy protection; Drugs; Human immunodeficiency virus; Metals; Performance evaluation; Polymers; Springs; Anti-HIV Agents; Anti-Infective Agents, Local; Contraceptive Devices, Female; Drug Implants; Equipment Design; Equipment Failure Analysis; Female; HIV Infections; Humans; Reproducibility of Results; Sensitivity and Specificity;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5627333

Filename

5627333