DocumentCode :
2943877
Title :
A new intact immobilization of liposome as sensing bio nano-particle on oxidized metal electrode surface
Author :
Noda, Masaki ; Takada, Kazumasa ; Nakai, Mitsuki ; Yamashita, Katsumi ; Shimanouchi, Takeaki ; Umakoshi, H.
Author_Institution :
Grad. Sch. of Sci. & Technol., Kyoto Inst. of Technol., Matsugasaki, Japan
fYear :
2012
fDate :
28-31 Oct. 2012
Firstpage :
1
Lastpage :
4
Abstract :
We newly report that the intactness of liposome on the electrode surfaces of Pt and Au metals could be significantly improved on thermally oxidized metal surfaces, compared to those with non-oxidization or even with a SAM treatment. It is especially noted that the sub-gel phase of lipid membrane of the liposome on the oxidized Pt surface is much more suppressed than the case of non-oxidized, indicating that the fluidity of intact liposome greatly improves, as the sub-gel phase then crystalline phase will increase when the intact liposome loses its closed spherical shape. Finally, the retention time of the intact liposome on the oxidized surface becomes improved to about one day. These results indicate that the oxidation treatment made the metal surface hydrophilic enough to keep the stable and intact liposome. We think that the retention time up to one day is good enough for practical biosensor applications using intact liposome to improve device performance and its reliabilities.
Keywords :
biosensors; electrodes; nanosensors; reliability; SAM treatment; bionanoparticle sensing; biosensor applications; crystalline phase; liposome intact immobilization; liposome lipid membrane; metal surface hydrophilic; oxidation treatment; oxidized metal electrode surface; reliabiltity; subgel phase; thermally oxidized metal surfaces; Biomembranes; Biosensors; Gold; Oxidation; Surface morphology; Surface treatment;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Sensors, 2012 IEEE
Conference_Location :
Taipei
ISSN :
1930-0395
Print_ISBN :
978-1-4577-1766-6
Electronic_ISBN :
1930-0395
Type :
conf
DOI :
10.1109/ICSENS.2012.6411074
Filename :
6411074
Link To Document :
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