Multimodal optical imaging for simultaneous in-vivo morphological and biochemical characterization of oral epithelial cancer

Author

Shrestha, Sebina ; Park, Jesung ; Pande, Paritosh ; Applegate, Brian E. ; Jo, Javier A.

Author_Institution

Dept. of Biomed. Eng., Texas A&M Univ., College Station, TX, USA

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

1970

Lastpage

1973

Abstract

Early detection of cancer is key to reducing morbidity and mortality. Morphological and chemical biomarkers presage the transition from normal to cancerous tissue. We have developed a noninvasive imaging system incorporating optical coherence tomography and fluorescence lifetime imaging to acquire both sets of biomarkers. Here we report early favorable results from an animal study designed to measure the capacity of this approach for early diagnosis of oral cancer.

Keywords

biochemistry; biological tissues; biomedical optical imaging; cancer; fluorescence; optical tomography; biochemical characterization; biomarkers; cancerous tissue; fluorescence lifetime imaging; morbidity; mortality; multimodal optical imaging; noninvasive imaging system; optical coherence tomography; oral epithelial cancer; simultaneous in-vivo morphological characterization; Animals; Biomedical optical imaging; Cancer; Fluorescence; Optical imaging; Fluorescence Lifetime Imaging Microscopy; Molecular Imaging; Multimodality Imaging; Optical Coherence Tomography; cancer diagnosis; Algorithms; Animals; Computer Simulation; Cricetinae; Dermoscopy; Diagnostic Imaging; Disease Models, Animal; Humans; Mesocricetus; Models, Statistical; Mouth Neoplasms; Neoplasms, Glandular and Epithelial; Optics and Photonics; Software; Tomography, Optical Coherence;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5627569

Filename

5627569