Title :
Experimental study and model of the physical chemical properties of liposome under ultrasonic irradiation
Author :
Furukawa, Roberto
Author_Institution :
Yamaguchi Univ., Yamaguchi, Japan
Abstract :
In the current method of drug administration for optimal dose and to the affected area (Drug Delivery System: DDS), a research of the study on permeability effect of liposome under external stimulation is conduced. Different conditions of ultrasonic irradiation are considered for experimental research such as time of irradiation, frequency of irradiation, position of the probe, water level, different concentration of liposomes and light. Due to a better understand of each stage of the process, a physical chemistry model is developed.
Keywords :
biochemistry; biological effects of acoustic radiation; biomedical ultrasonics; biomembrane transport; cellular effects of radiation; drug delivery systems; lipid bilayers; permeability; cell membrane; chemical properties; drug administration; drug delivery system; lipids; liposome; medical treatment; optimal dose; permeability effect; physical properties; ultrasonic irradiation frequency; water level; Biomembranes; Fluorescence; Permeability; Probes; Radiation effects; Time frequency analysis; Ultrasonic imaging;
Conference_Titel :
Biomedical Robotics and Biomechatronics (BioRob), 2010 3rd IEEE RAS and EMBS International Conference on
Conference_Location :
Tokyo
Print_ISBN :
978-1-4244-7708-1
DOI :
10.1109/BIOROB.2010.5628006
