Experimental study and model of the physical chemical properties of liposome under ultrasonic irradiation

Author

Furukawa, Roberto

Author_Institution

Yamaguchi Univ., Yamaguchi, Japan

fYear

2010

fDate

26-29 Sept. 2010

Firstpage

843

Lastpage

848

Abstract

In the current method of drug administration for optimal dose and to the affected area (Drug Delivery System: DDS), a research of the study on permeability effect of liposome under external stimulation is conduced. Different conditions of ultrasonic irradiation are considered for experimental research such as time of irradiation, frequency of irradiation, position of the probe, water level, different concentration of liposomes and light. Due to a better understand of each stage of the process, a physical chemistry model is developed.

Keywords

biochemistry; biological effects of acoustic radiation; biomedical ultrasonics; biomembrane transport; cellular effects of radiation; drug delivery systems; lipid bilayers; permeability; cell membrane; chemical properties; drug administration; drug delivery system; lipids; liposome; medical treatment; optimal dose; permeability effect; physical properties; ultrasonic irradiation frequency; water level; Biomembranes; Fluorescence; Permeability; Probes; Radiation effects; Time frequency analysis; Ultrasonic imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Robotics and Biomechatronics (BioRob), 2010 3rd IEEE RAS and EMBS International Conference on

Conference_Location

Tokyo

ISSN

2155-1774

Print_ISBN

978-1-4244-7708-1

Type

conf

DOI

10.1109/BIOROB.2010.5628006

Filename

5628006