Title :
Laser-induced endogenous fluorescence as possible response predictor of neoadjuvant treatment of rectal cancer
Author :
Ebert, B. ; Sukowski, U. ; Rinneberg, H. ; Balanou, P. ; Moesta, K.T. ; Handke, T. ; Rau, B. ; Schlag, Peter M.
Author_Institution :
Phys. Tech. Bundesanstalt, Braunschweig, Germany
Abstract :
Summary form only. Response to neoadjuvant treatment (radiochemotherapy: RCT; radiochemotherapy with hyperthermia: HRCT) can not be monitored precisely by present clinical diagnostic tools. It was observed previously that autofluorescence spectra of tumors recorded ex vivo or in vivo exhibit strong porphyrin fluorescence bands. Following a prospective, randomized protocol to compare hyperthermic radiochemotherapy with radiochemotherapy alone for treating regionally advanced rectal cancer, we have recorded time-gated autofluorescence spectra and evaluated changes in PpIX fluorescence intensity of primary tumors and surrounding mucosa. Our aim is to demonstrate that laser-induced fluorescence intensity of endogenous porphyrins can be used as marker for biological tumor response.
Keywords :
biomedical measurement; cancer; fluorescence; hyperthermia; laser applications in medicine; patient diagnosis; radiochemistry; tumours; PpIX fluorescence intensity; advanced rectal cancer; autofluorescence spectra; biological tumor response; clinical diagnostic tools; endogenous porphyrins; ex vivo; hyperthermia; hyperthermic radiochemotherapy; in vivo; laser-induced endogenous fluorescence; neoadjuvant treatment; radiochemotherapy; rectal cancer; response predictor; strong porphyrin fluorescence bands; time-gated autofluorescence spectra; tumors; Biomedical optical imaging; Biopsy; Fluorescence; Image resolution; Optical imaging; Optical pumping; Probes; Pump lasers; Rain; Viscosity;
Conference_Titel :
Lasers and Electro-Optics Europe, 2000. Conference Digest. 2000 Conference on
Conference_Location :
Nice
Print_ISBN :
0-7803-6319-1
DOI :
10.1109/CLEOE.2000.910311
