High-Resolution 1H NMR Micro spectroscopy using an Implantable Micro-coil

This study presents a new concept of implantable micro coil (1000 times 500 mum²) fabricated using an electroplating technique, used as receiver coil at 200 MHz for the measurement of small volumes and concentrations samples by NMR spectroscopy. Our goal is to determine its concentration sensitivity S_c and its limit of detection LOD. The MRI and simulation of RF field distribution allows defining an active volume of 0.8 muL. The spectroscopic results show that the S_c is closed to 0.2691 mM^-1 and LOD of 11.1 mM. This micro-system offers the possibility of new investigation techniques like local cerebral metabolites occupying small volumes (muL to nL).