Title :
The closed-loop regulation of blood glucose in diabetics
Author :
Woodruff, E.A. ; Gulaya, S. ; Northrop, R.B.
Author_Institution :
Dept. of Electr. & Syst. Eng., Connecticut Univ., Storrs, CT, USA
Abstract :
The development of a system for the closed-loop regulation of blood glucose concentration (BGC) in a Type-1 diabetic when sparse measurements of the blood glucose concentration are available is discussed. A model reference technique to provide an estimate of the BGC is implemented. Whenever, a BGC measurement is not available, the BGC estimate is used in the controller realization. After developing the model reference offline, a computer simulation is realized for closed-loop regulation of blood glucose concentration in a Type-1 diabetic. A recursive parameter-estimation scheme is implemented to update the parameters of the model reference throughout the closed-loop simulation. These parameter estimates can be used to adjust some of the controller parameters to enhance the robustness of the controller
Keywords :
biocontrol; blood; closed loop systems; blood glucose; closed-loop regulation; computer simulation; controller parameters; diabetics; model reference technique; recursive parameter-estimation scheme; Algorithm design and analysis; Blood; Computational modeling; Diabetes; Digital control; Insulin; PD control; Parameter estimation; Sugar; Systems engineering and theory;
Conference_Titel :
Bioengineering Conference, 1988., Proceedings of the 1988 Fourteenth Annual Northeast
Conference_Location :
Durham, NH
DOI :
10.1109/NEBC.1988.19342
