Modeling of electro-mechanics in left ventricle

Modeling of cardiac electro-mechanics can enhance the understanding of the physiology and pathophysiology of the heart. A model of the left ventricle is presented, which allows the reconstruction of electrical and mechanical processes with inclusion of feedback mechanisms. The model combines a three-dimensional model of left ventricular anatomy with electrophysiological and force development models of cardiac myocytes as well as models of the electrical current flow and the passive mechanics of the myocardium. Results of simulations are the temporal distribution of electrical propagation and mechanical deformation, which show the connection between cellular electrophysiology, electrical excitation propagation, force development, and mechanical deformation.