DocumentCode
2971750
Title
Spatial control of cavitation: theoretical and experimental validation of a dual-frequency excitation method
Author
Sokka, Sham D. ; Gauthier, Thomas P. ; Hynynen, Kullervo
Author_Institution
Brigham & Women´´s Hosp., Harvard Med. Sch., Boston, MA, USA
Volume
2
fYear
2004
fDate
23-27 Aug. 2004
Firstpage
878
Abstract
Inertial cavitation has been implicated as the primary mechanism for a host of emerging applications. In all these applications, the main concern is to induce cavitation in perfectly controlled locations in the field, this means specifically to be able to achieve cavitation threshold at the geometrical focus of the transducer without stimulating its near field. In this study, we develop dual-frequency methods to preferentially lower the cavitation threshold at the focus relative to the rest of the field. One family of dual-frequency driving waveforms is evaluated in a bubble model incorporating rectified diffusion. Results are then verified by experiment. Finally, the performance of the rest of the acoustic field in suppressing cavitation when cavitation is induced at the focus is investigated theoretically and checked experimentally. This study shows that dual-frequency phased arrays could be used to precisely control cavitation. The cavitation threshold is proved to be almost 1.3 times higher in the near field than at the focus. The concept of cavitation field is introduced and complements cavitation studies concentrating on the focal behavior only.
Keywords
acoustic field; biomedical ultrasonics; cavitation; patient treatment; ultrasonic arrays; ultrasonic transducers; acoustic field; bubble model; cavitation field; cavitation threshold; dual-frequency driving waveforms; dual-frequency excitation method; dual-frequency phased arrays; inertial cavitation; rectified diffusion; spatial cavitation control; transducer geometrical focus; Acoustic transducers; Drug delivery; Equations; Frequency; Gene therapy; Heating; Hospitals; Medical treatment; Phased arrays; Tissue damage;
fLanguage
English
Publisher
ieee
Conference_Titel
Ultrasonics Symposium, 2004 IEEE
ISSN
1051-0117
Print_ISBN
0-7803-8412-1
Type
conf
DOI
10.1109/ULTSYM.2004.1417875
Filename
1417875
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