Title :
Spatial control of cavitation: theoretical and experimental validation of a dual-frequency excitation method
Author :
Sokka, Sham D. ; Gauthier, Thomas P. ; Hynynen, Kullervo
Author_Institution :
Brigham & Women´´s Hosp., Harvard Med. Sch., Boston, MA, USA
Abstract :
Inertial cavitation has been implicated as the primary mechanism for a host of emerging applications. In all these applications, the main concern is to induce cavitation in perfectly controlled locations in the field, this means specifically to be able to achieve cavitation threshold at the geometrical focus of the transducer without stimulating its near field. In this study, we develop dual-frequency methods to preferentially lower the cavitation threshold at the focus relative to the rest of the field. One family of dual-frequency driving waveforms is evaluated in a bubble model incorporating rectified diffusion. Results are then verified by experiment. Finally, the performance of the rest of the acoustic field in suppressing cavitation when cavitation is induced at the focus is investigated theoretically and checked experimentally. This study shows that dual-frequency phased arrays could be used to precisely control cavitation. The cavitation threshold is proved to be almost 1.3 times higher in the near field than at the focus. The concept of cavitation field is introduced and complements cavitation studies concentrating on the focal behavior only.
Keywords :
acoustic field; biomedical ultrasonics; cavitation; patient treatment; ultrasonic arrays; ultrasonic transducers; acoustic field; bubble model; cavitation field; cavitation threshold; dual-frequency driving waveforms; dual-frequency excitation method; dual-frequency phased arrays; inertial cavitation; rectified diffusion; spatial cavitation control; transducer geometrical focus; Acoustic transducers; Drug delivery; Equations; Frequency; Gene therapy; Heating; Hospitals; Medical treatment; Phased arrays; Tissue damage;
Conference_Titel :
Ultrasonics Symposium, 2004 IEEE
Print_ISBN :
0-7803-8412-1
DOI :
10.1109/ULTSYM.2004.1417875