DocumentCode :
2975629
Title :
CAN breathing oscillations reduce asthma medication?
Author :
Mathur, M. ; Al-Jumaily, A.M. ; Ijpma, G. ; Alany, R.
Author_Institution :
Inst. of Biomed. Technol., Auckland Univ. of Technol., Auckland, New Zealand
fYear :
2011
fDate :
21-24 Feb. 2011
Firstpage :
1
Lastpage :
4
Abstract :
Airway hyperresponsiveness and obstruction are the major characteristics of asthma. Current asthma treatments using anti-inflammatory agents and airway smooth muscle (ASM) relaxants are expensive, variable in effectiveness and are associated with several cardiovascular side effects. ASM behaviour in vitro has been studied by various researchers to possibly provide an explanation of its mechanical properties. Previous in vitro experiments conducted on ASM tissues suggest that length perturbations applied to contracted muscle result in a reduction in the contractile ability of the tissue. This study focuses on investigating the combined effects of bronchodilators and length oscillations on the dynamics of contracted ASM. Isolated porcine tracheal smooth muscle tissues are contracted using Acetylcholine. Isoproterenol (Iso), a β-agonist, is used as a bronchodilator to relax the contracted ASM. Our results suggest that the combined effect of Iso and breathing oscillations is noted to be greater than the added effects of Iso and breathing alone. We speculate that, when breathing is combined with Iso, breathing facilitates the detachment of actomyosin bridges, while Iso prevents further phosphorylation of myosin heads, inhibiting the binding of myosin to actin.
Keywords :
biological tissues; biomechanics; cardiovascular system; diseases; muscle; oscillations; patient treatment; pneumodynamics; β-agonist; ASM tissues; acetylcholine; actomyosin bridges; airway hyperresponsiveness; airway smooth muscle; anti-inflammatory agents; asthma medication; breathing oscillations; bronchodilators; cardiovascular side effects; isolated porcine tracheal smooth muscle; isoproterenol; myosin heads; phosphorylation; Analysis of variance; Bridges; Force; In vitro; Muscles; Oscillators; Strips;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Engineering (MECBME), 2011 1st Middle East Conference on
Conference_Location :
Sharjah
Print_ISBN :
978-1-4244-6998-7
Type :
conf
DOI :
10.1109/MECBME.2011.5752051
Filename :
5752051
Link To Document :
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