Title :
Investigating the effect of different targets in deep brain stimulation on symptoms of Parkinson´s disease using a mean-field model of the basal ganglia-thalamocortical system
Author :
Nahvi, Alireza ; Bahrami, Fariba
Author_Institution :
Sch. of Electr. & Comput. Eng., Univ. of Tehran, Tehran, Iran
Abstract :
In this paper, we investigated effects of deep brain stimulation (DBS) on Parkinson´s disease (PD) when different target sites in the basal ganglia are stimulated. The targets which are investigated are subthalamic nucleus (STN), globus pallidus interna (GPi), and globus pallidus externa (GPe). For this purpose we used a computational model of the basal ganglia-thalamocortical system (BGTCS) with parameters calculated for mean field. This model is able to reproduce both the normal and parkinsonian activities of basal ganglia, thalamus and cortex in a unified structure. Our results suggest that DBS in the STN and GPe could restore the thalamus relay activity, while DBS in the GPi could inhibit it. Our results are compatible with the experimental and the clinical outcomes about the effects of DBS of different targets.
Keywords :
bioelectric potentials; brain; diseases; neurophysiology; patient diagnosis; Parkinson disease symptoms; basal ganglia-thalamocortical system; computational model; deep brain stimulation; electrical stimulation; globus pallidus externa; globus pallidus interna; mean-field model; subthalamic nucleus; thalamus relay activity; Basal ganglia; Brain modeling; Brain stimulation; Computational modeling; Firing; Relays; Satellite broadcasting; Introduction (Heading 1); Mean field model; Parkinson´s disease; basal ganglia thalamocortical system; deep brain stimulation;
Conference_Titel :
Biomedical Engineering (MECBME), 2011 1st Middle East Conference on
Conference_Location :
Sharjah
Print_ISBN :
978-1-4244-6998-7
DOI :
10.1109/MECBME.2011.5752089
