Exploring protein functions correlation based on overlapping proteins and cluster interactions

Usually, the relations between the protein functions do not be considered in protein function/interaction prediction. In this paper, we propose a strategy for determining the relation between the protein functions. The technique is based on the overlapping number of proteins and interactions over protein clusters to determine the correlation between the sub-function categories as well as improve the protein function prediction process. The proposed method was applied to yeast proteome and the results revealed great improvement in increasing the degree of certainty and accuracy for protein function prediction.