Exploring Centrality-Lethality Rule from Evolution Constraint on Essential Hub and Nonessential Hub in Yeast Protein-Protein Interaction Network

Author

Yun-yuan, Dong ; Jun, Yang ; Qi-jun, Liu ; Yong-xian, Wang ; Zheng-hua, Wang

Author_Institution

Coll. of Comput., Nat. Univ. of Defense Technol., Changsha, China

fYear

2011

fDate

3-4 Dec. 2011

Firstpage

63

Lastpage

65

Abstract

In the analysis of Protein-Protein Interaction (PPI) network, one intriguing problem is the reason for centrality-lethality rule. To discover the relationship between topological properties and functional features of proteins in PPI network, we classified hub proteins into two types: essential hub and nonessential hub and combined proteins´ topological structure and evolutionary rate information together. We found that essential hub proteins tend to be intra-modular hubs and they had higher evolutionary conservation, nonessential hub proteins tend to be inter-modular hubs and they had lower evolutionary conservation.

Keywords

evolution (biological); microorganisms; molecular biophysics; proteins; centrality-lethality rule; evolutionary rate information; functional features; intramodular hubs; topological properties; yeast protein-protein interaction network; Bioinformatics; Correlation; Educational institutions; Evolution (biology); Genomics; Proteins; centrality; essential hub; evolutionary rate; nonessential hub; protein-protein interaction network;

fLanguage

English

Publisher

ieee

Conference_Titel

Computational Intelligence and Security (CIS), 2011 Seventh International Conference on

Conference_Location

Hainan

Print_ISBN

978-1-4577-2008-6

Type

conf

DOI

10.1109/CIS.2011.22

Filename

6128075